Sexual dimorphism may affect human physiology and illness. Individual differences in men and women can have major physiological effects and disease outcomes. Protein-coding gene activities would depend on tissue-specific expression profiles, which may further cause physiological variations. Individual human tissue-specific gene expression patterns must be extensively analyzed. Therefore, this TPSDG user-friendly bioinformatic tool for viewing expression levels and variations across individual samples in specified tissues was generated We used the Gini coefficient index and the latest GTEx V10 datasets to compare human protein-coding gene expression across 43 tissue subtypes. The Gini coefficient index was used to compare male and female expression across all tissue subtypes. This visualization webtool provides tissue-specific expression profiles for individual male and female subjects. Particularly, this tool enables users to simultaneously interrogate the Gini index profiles (variations) and expression levels of protein-coding genes across various tissue subtypes. Thus, this TPSDG bioinformatic webtool is useful for biological researchers investigating divergently expressed protein-coding genes across different tissues.

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By Gene Symbol :   (1) Gene Symbol : 

(2) Tissue :  Select adipose_subcutaneous adipose_visceral_omentum adrenal_gland artery_aorta artery_coronary artery_tibial bladder brain_amygdala brain_anterior_cingulate_cortex_ba24 brain_caudate_basal_ganglia brain_cerebellar_hemisphere brain_cerebellum brain_cortex brain_frontal_cortex_ba9 brain_hippocampus brain_hypothalamus brain_nucleus_accumbens_basal_ganglia brain_putamen_basal_ganglia brain_spinal_cord_cervical_c-1 brain_substantia_nigra breast_mammary_tissue colon_sigmoid colon_transverse esophagus_gastroesophageal_junction esophagus_mucosa esophagus_muscularis heart_atrial_appendage heart_left_ventricle kidney_cortex liver lung minor_salivary_gland muscle_skeletal nerve_tibial pancreas pituitary skin_not_sun_exposed_suprapubic skin_sun_exposed_lower_leg small_intestine_terminal_ileum spleen stomach thyroid whole_blood   Submit

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By Tissue & Z-score : 

(1) Z-score cutoff :  1.96 2.58

(2) Gene TPM :  0.1 0.5 1.0 5 10

(3) Chromosome :  1~22 XY

(4) Tissue type

(5) M<F or M>F

Cardiovascular: ▼
Artery_Aorta M < F M > F Artery_Coronary M < F M > F Artery_Tibial M < F M > F Heart_Atrial Appendage M < F M > F Heart_Left Ventricle M < F M > F

Digestion:        ▶
Liver M < F M > F Minor Salivary Gland M < F M > F Esophagus_Gastroesophageal Junction M < F M > F Esophagus_Mucosa M < F M > F Esophagus_Muscularis M < F M > F Stomach M < F M > F Small Intestine_Terminal ileum M < F M > F Colon_Sigmoid M < F M > F Colon_Transverse M < F M > F

Endocrine:       ▶
Thyroid M < F M > F Pancreas M < F M > F Pituitary M < F M > F Adrenal Gland M < F M > F

Integumentary:         ▶
Skin_Not Sun Exposed M < F M > F Skin_Sun Exposed M < F M > F Adipose_Subcutaneous M < F M > F Adipose_Visceral M < F M > F

Lymphatic:           ▶
Spleen M < F M > F Whole Blood M < F M > F

Nervous: ▶

Brain_Amygdala M < F M > F Brain_Anterior Cingulate cortex M < F M > F Brain_Caudate M < F M > F Brain_Cerebellar Hemisphere M < F M > F Brain_Cerebellum M < F M > F Brain_Cortex M < F M > F Brain_Frontal Cortex M < F M > F Brain_Hippocampus M < F M > F Brain_Hypothalamus M < F M > F Brain_Nucleus accumbens M < F M > F Brain_Putamen M < F M > F Brain_Spinal cord M < F M > F Brain_Substantia nigra M < F M > F Nerve_Tibial M < F M > F

Muscle: ▶
Muscle_Skeletal M < F M > F

Respiratory:   ▶
Lung M < F M > F

Reproductive:   ▶
Breast_Mammary Tissue M < F M > F

Urinary:           ▶
Kidney Cortex M < F M > F Bladder M < F M > F